Description

(6R,23S,25S)-5-o-Demethyl-28-Deoxy-6,28-Epoxy-23-Hydroxy-25-(1-Methyl-1-Butenyl)Milbemycin B is a semi-synthetic derivative of the potent milbemycin family of macrocyclic lactones, valued for its high biological activity. This compound is a critical intermediate in the synthesis of advanced veterinary and agricultural acaricides and anthelmintics, offering a strategic building block for developing next-generation parasitic control agents. It is primarily sought by manufacturers in the animal health and crop protection industries for research, development, and production of high-efficacy formulations.

Application

• Key Intermediate for Acaricide Synthesis: Serves as a crucial precursor in the manufacturing of novel milbemycin-based acaricides for agricultural use.
• Veterinary Antiparasitic Development: Used in R&D and production of endectocides and anthelmintics for livestock and companion animals.
• Agrochemical Research: A vital compound for developing new active ingredients with enhanced potency and spectrum against mites and ticks.
• Biochemical Studies: Employed in pharmacological and mode-of-action research targeting invertebrate GABA-gated chloride channels.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and regulatory testing of milbemycin-derived products.
• Custom Synthesis Building Block: Provides a versatile core structure for the custom synthesis of specialized milbemycin analogs.

Basic Information

Product Name	(6R,23S,25S)-5-o-Demethyl-28-Deoxy-6,28-Epoxy-23-Hydroxy-25-(1-Methyl-1-Butenyl)Milbemycin B
CAS No.	102042-16-0
Molecular Formula	C₃₂H₄₆O₇
Molecular Weight	542.71 g/mol
Synonyms	5-O-Demethyl-28-deoxy-6,28-epoxy-23-hydroxy-25-(1-methyl-1-butenyl)milbemycin B; Milbemycin B derivative; 28-Deoxymilbemycin B derivative; 6,28-Epoxy-23-hydroxymilbemycin; (6R,23S,25S)-Milbemycin intermediate; LL-F28249 derivative; Nemadectin precursor
EINECS	Contact for details

Quality Control

Our (6R,23S,25S)-5-o-Demethyl-28-Deoxy-6,28-Epoxy-23-Hydroxy-25-(1-Methyl-1-Butenyl)Milbemycin B is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting standards for use in pharmaceutical and agrochemical synthesis. Certificates of Analysis (COA) detailing all specifications are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.