Description

Zardaverine CAS NO 101975-10-4 is a selective phosphodiesterase 4 (PDE4) inhibitor, representing a key intermediate and active pharmaceutical ingredient (API) in advanced therapeutic research. Its primary value lies in its potent anti-inflammatory and bronchodilatory properties, making it a critical compound for developing novel treatments for respiratory and inflammatory diseases. This high-purity chemical is essential for pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and academic institutions focused on pulmonary pharmacology and new drug discovery.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of advanced PDE4 inhibitor drug candidates.
• Respiratory Disease Research: Used in preclinical and clinical research for chronic obstructive pulmonary disease (COPD) and asthma due to its bronchodilatory effects.
• Anti-inflammatory Agent Development: Applied in studies targeting inflammatory conditions such as psoriasis, rheumatoid arthritis, and atopic dermatitis.
• Biochemical Tool Compound: Utilized in vitro and in vivo to study PDE4 enzyme activity and intracellular cAMP signaling pathways.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Academic & Institutional Research: Supports fundamental pharmacological research in university and government laboratories.

Basic Information

Product Name	Zardaverine
CAS No.	101975-10-4
Molecular Formula	C20H21N3O4
Molecular Weight	367.40 g/mol
Synonyms	Zardaverine; B9002-0771; CHEMBL2103879; BRN 1090585; 6-[4-(Difluoromethoxy)-3-methoxyphenyl]-3(2H)-pyridazinone; 4a,5,6,7,8,8a-Hexahydro-4H-thieno[3,2-e]isoindole-8-carboxylic acid methyl ester (related precursor); PDE4 Inhibitor Zardaverine
EINECS	Contact for details

Quality Control

Our Zardaverine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and rigorous tests for residual solvents and heavy metals. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept tightly sealed in a dry environment. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.