Description

4-(Iodomethyl)Tetrahydro-2H-Pyran is a versatile halogenated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the reactive iodomethyl group, which facilitates efficient carbon-carbon bond formation and functional group transformations under mild conditions. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to construct complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) and anti-infective agents.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and plant growth regulators, where the tetrahydro-2H-pyran moiety can enhance bioavailability and stability.
• Ligand and Catalyst Precursor: Serves as a starting material for the synthesis of chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the creation of functionalized polymers and dendritic structures with tailored properties.
• Cross-Coupling Reactions: Acts as an efficient electrophile in various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to introduce functionalized tetrahydropyranyl units.
• Radical Chemistry: The carbon-iodine bond is a useful precursor for generating radicals in chain reactions for complex molecule construction.

Basic Information

Product Name	4-(Iodomethyl)Tetrahydro-2H-Pyran
CAS No.	101691-94-5
Molecular Formula	C6H11IO
Molecular Weight	226.06 g/mol
Synonyms	4-(Iodomethyl)oxane; Tetrahydro-2H-pyran-4-ylmethyl iodide; 4-(Iodomethyl)tetrahydropyran; 4-Iodomethyltetrahydropyran; Oxan-4-ylmethyl iodide; 4-Pyranylmethyl iodide, tetrahydro-; (Oxan-4-yl)methyl iodide
EINECS	Contact for details

Quality Control

Our 4-(Iodomethyl)Tetrahydro-2H-Pyran is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and iodometric titration, to ensure high chemical purity and consistent performance. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO 9001 standards for reliable supply to regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive nature, the material should be handled under subdued light and the container kept sealed when not in use to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Specific Gravity	1.70 - 1.90 g/mL @ 20°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.