Description

(S)-2-Mercaptomethyl-Pyrrolidine-1-Carboxylic Acid Benzyl Ester is a high-purity chiral building block of significant importance in modern synthetic chemistry. Its value lies in its role as a key intermediate for constructing complex molecules with defined stereochemistry, which is critical for biological activity. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for applications in asymmetric synthesis and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the multi-step synthesis of potential drug candidates, especially those targeting neurological and metabolic disorders.
• Asymmetric Catalyst Ligand Precursor: Used to develop novel ligands for transition metal catalysts, enabling highly enantioselective transformations.
• Peptidomimetic Research: Serves as a constrained proline analogue for the design and synthesis of peptide-like molecules with enhanced stability and bioavailability.
• Chemical Biology Probes: Employed in the synthesis of tool compounds for studying enzyme mechanisms and protein-protein interactions.
• Process Chemistry Development: Used in route scouting and optimization for the scalable production of enantiomerically pure compounds.
• Academic Research: A valuable reagent for methodological studies in organic synthesis, particularly in the formation of sulfur-containing heterocycles.

Basic Information

Product Name	(S)-2-Mercaptomethyl-Pyrrolidine-1-Carboxylic Acid Benzyl Ester
CAS No.	101250-73-1
Molecular Formula	C13H17NO2S
Molecular Weight	251.34 g/mol
Synonyms	(S)-1-(Benzyloxycarbonyl)-2-(mercaptomethyl)pyrrolidine; (S)-N-Cbz-2-(Mercaptomethyl)pyrrolidine; (S)-2-(Mercaptomethyl)-1-pyrrolidinecarboxylic Acid Benzyl Ester; (S)-1-Benzyl 2-(Mercaptomethyl)pyrrolidine-1-carboxylate; L-Proline, 2-(mercaptomethyl)-, 1-(phenylmethyl) ester; Cbz-(S)-2-Mercaptomethyl-pyrrolidine; Z-(S)-2-Mercaptomethyl-pyrrolidine; (S)-2-Mercaptomethyl-1-carbobenzyloxypyrrolidine
EINECS	Contact for details

Quality Control

Our (S)-2-Mercaptomethyl-Pyrrolidine-1-Carboxylic Acid Benzyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, purity, and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and maintain stability. The container should be kept in a cool, dry, and well-ventilated place, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.