Description

Akiyama's Reagent is a specialized organoboron compound, identified by CAS No. 101046-20-2, widely recognized for its role as a key catalyst and reagent in modern synthetic organic chemistry. Its primary value lies in enabling highly efficient and stereoselective carbon-carbon bond-forming reactions, which are fundamental to constructing complex molecular architectures. This reagent is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors, where precision synthesis is critical.

Application

• Asymmetric Synthesis Catalyst: A key component in the Akiyama reaction for the enantioselective synthesis of chiral compounds.
• Pharmaceutical Intermediate Production: Used in the synthesis of active pharmaceutical ingredients (APIs) requiring high stereochemical purity.
• Agrochemical Research: Employed in the development of novel herbicides and pesticides with specific chiral activity.
• Material Science: Facilitates the creation of specialized polymers and organic electronic materials with tailored properties.
• Academic & Industrial R&D: A vital tool for methodological development in organic synthesis laboratories worldwide.
• Fine Chemical Manufacturing: Used in the production of high-value, complex fragrance and flavor intermediates.

Basic Information

Product Name	Akiyama's Reagent
CAS No.	101046-20-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(R)-3,3'-Bis(2,4,6-triisopropylphenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; (R)-TRIP; Akiyama Catalyst; (R)-3,3'-Bis(2,4,6-triisopropylphenyl)-1,1'-binaphthyl-2,2'-diyl phosphate; TRIP Phosphoric Acid; BINOL-derived phosphoric acid catalyst.
EINECS	Contact for details

Quality Control

Our Akiyama's Reagent is produced under stringent quality management protocols to ensure batch-to-batch consistency and high catalytic performance. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and chiral analysis to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.