Description

2-[6,7-Dimethoxy-2-(Methylsulfonyl)-1,2,3,4-Tetrahydroisoquinolin-1-Yl]Acetohydrazide is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound matters for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting neurological and cardiovascular pathways. Pharmaceutical R&D teams and fine chemical manufacturers need this precise intermediate to develop next-generation therapeutic agents with high efficacy and specificity.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel tetrahydroisoquinoline-based drug candidates for central nervous system (CNS) disorders.
• Research & Development: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a core scaffold for developing potential therapeutics targeting hypertension, anxiety, or Parkinson's disease.
• Biochemical Research: Employed as a tool compound in pharmacological assays to study receptor binding and enzyme inhibition.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.
• Academic Research: Utilized in university and institutional labs for exploring new synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	2-[6,7-Dimethoxy-2-(Methylsulfonyl)-1,2,3,4-Tetrahydroisoquinolin-1-Yl]Acetohydrazide
CAS No.	100879-60-5
Molecular Formula	C₁₄H₁₉N₃O₅S
Molecular Weight	341.38 g/mol
Synonyms	1,2,3,4-Tetrahydro-6,7-dimethoxy-2-(methylsulfonyl)-1-isoquinolineacetohydrazide; 2-(6,7-Dimethoxy-2-methylsulfonyl-3,4-dihydro-1H-isoquinolin-1-yl)acetohydrazide; 2-[6,7-Dimethoxy-2-(methylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-1-yl]acetohydrazide; 1-Isoquinolineacetohydrazide, 1,2,3,4-tetrahydro-6,7-dimethoxy-2-(methylsulfonyl)-; 2-(6,7-Dimethoxy-2-methylsulfonyl-1,2,3,4-tetrahydroisoquinolin-1-yl)acetohydrazide; 100879-60-5; 2-(6,7-dimethoxy-2-methylsulfonyl-3,4-dihydro-1H-isoquinolin-1-yl)acetohydrazide
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for pharmaceutical intermediates. Each batch is characterized and controlled using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and consistency. Certificates of Analysis (COA) are available upon request, detailing batch-specific results. We adhere to a quality management system and can support development under ICH guidelines for impurity profiling and stability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation and to minimize degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.