Description

5-(Trifluoromethyl)Indole is a versatile fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the unique electronic and steric properties imparted by the trifluoromethyl group, which is crucial for modulating the biological activity and physicochemical characteristics of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for developing potential drug candidates, particularly in oncology, CNS disorders, and anti-inflammatory therapies.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides where the CF3 group enhances lipophilicity and metabolic stability.
• Material Science: Serves as a precursor for specialty polymers, liquid crystals, and organic electronic materials requiring specific fluorinated motifs.
• Chemical Biology: Employed as a probe or tag in medicinal chemistry for structure-activity relationship (SAR) studies due to its distinct spectroscopic signature.
• Academic & Contract Research: A valuable reagent for methodological development in organic chemistry, including cross-coupling and C-H functionalization reactions.

Basic Information

Product Name	5-(Trifluoromethyl)Indole
CAS No.	100846-24-0
Molecular Formula	C9H6F3N
Molecular Weight	185.15 g/mol
Synonyms	1H-Indole, 5-(trifluoromethyl)-; 5-(Trifluoromethyl)-1H-indole; 5-Trifluoromethylindole; 5-CF3-Indole; α,α,α-Trifluoro-m-toluidine, indole derivative; Indole, 5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethyl)Indole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for use in regulated research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.