Description

4-Amino-1-(Phenylsulfonyl)-Indole is a specialized indole derivative featuring a phenylsulfonyl protecting group at the N1 position and an amino substituent at the 4-position. This unique molecular architecture makes it a valuable pharmaceutical intermediate and a versatile building block for medicinal chemistry research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for the synthesis of novel drug candidates, particularly those targeting central nervous system disorders.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex bioactive molecules and potential drug candidates.
• Medicinal Chemistry Research: Serves as a crucial building block for constructing indole-based compound libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Organic Synthesis: Used in palladium-catalyzed cross-coupling reactions, such as Buchwald-Hartwig amination, to introduce the amino functionality into more complex structures.
• Chemical Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.
• Academic Research: Utilized in university and institutional labs for investigating novel heterocyclic chemistry and reaction methodologies.

Basic Information

Product Name	4-Amino-1-(Phenylsulfonyl)-Indole
CAS No.	100557-22-0
Molecular Formula	C14H12N2O2S
Molecular Weight	272.32 g/mol
Synonyms	1-(Phenylsulfonyl)-1H-indol-4-amine; 4-Amino-1-(benzenesulfonyl)-1H-indole; 4-Amino-1H-indole-1-sulfonic acid phenyl ester; 4-Aminoindole-1-sulfonamide, N-phenyl-; 1H-Indole-4-amine, 1-(phenylsulfonyl)-; 4-Amino-1-(phenylsulfonyl)indole
EINECS	Contact for details

Quality Control

Our 4-Amino-1-(Phenylsulfonyl)-Indole is produced under a strict quality management system. Every batch undergoes rigorous analytical testing to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles as confirmed by HPLC, NMR, and mass spectrometry. Our quality commitment ensures the material meets the exacting standards required for pharmaceutical R&D and advanced organic synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.