Description

3-Mercapto-Pyrrolidine-1-Carboxylic Acid Benzyl Ester is a versatile chiral building block and intermediate of significant importance in advanced organic synthesis. Its core value lies in the presence of both a protected carboxylic acid group and a reactive thiol functionality, enabling its use in the construction of complex molecules, particularly in pharmaceutical research. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications such as peptidomimetics and heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, enzyme modulators, and other bioactive molecules.
• Peptidomimetic Scaffold: Used in the design and construction of peptide analogs where the pyrrolidine ring and thiol group mimic natural amino acid side chains.
• Ligand Synthesis: Serves as a precursor for chelating agents and catalysts in asymmetric synthesis.
• Agrochemical Research: Employed as a building block for novel active ingredients requiring specific stereochemistry.
• Material Science: Potential monomer or cross-linking agent in the development of specialty polymers.
• Chemical Biology Probes: Useful for bioconjugation and labeling studies due to the reactive thiol group.

Basic Information

Product Name	3-Mercapto-Pyrrolidine-1-Carboxylic Acid Benzyl Ester
CAS No.	100472-48-8
Molecular Formula	C12H15NO2S
Molecular Weight	237.32 g/mol
Synonyms	Benzyl 3-Mercaptopyrrolidine-1-carboxylate; 1-(Benzyloxycarbonyl)-3-mercaptopyrrolidine; 3-Mercapto-1-[(phenylmethoxy)carbonyl]pyrrolidine; Cbz-3-mercaptopyrrolidine; 1-Carbobenzyloxy-3-mercaptopyrrolidine; 3-Thiol-pyrrolidine-1-carboxylic acid benzyl ester; (3-Mercaptopyrrolidin-1-yl)(phenyl)methanone benzyl ester; NSC 405124
EINECS	Contact for details

Quality Control

Our 3-Mercapto-Pyrrolidine-1-Carboxylic Acid Benzyl Ester is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity assessment, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation of the thiol group and ensure product stability. Keep the container in a dry, well-ventilated place.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (enantiomeric excess)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.