Description

1,3,4,5,6,11A-Hexahydro-2-Methyl-2H-3,6A-Methanobenzofuro(2,3-C)Azocin-10-Ol is a complex, high-purity organic compound with a unique bridged polycyclic structure, serving as a critical advanced intermediate in pharmaceutical research and development. Its value lies in enabling the synthesis of novel active pharmaceutical ingredients (APIs) and complex molecules for therapeutic applications. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries seeking to develop new drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex alkaloid-like molecules and potential central nervous system (CNS) active compounds.
• Medicinal Chemistry Research: Used as a scaffold or precursor for designing and testing new chemical entities (NCEs) in drug discovery programs.
• Process Chemistry Development: Serves as a critical intermediate for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions for clinical trial material production.
• Academic & Institutional Research: Employed in universities and research institutes for studying complex organic reactions, heterocyclic chemistry, and structure-activity relationships (SAR).
• Fine Chemical Synthesis: Utilized in the custom synthesis of specialty chemicals, reference standards, and other high-value, low-volume products.

Basic Information

Product Name	1,3,4,5,6,11A-Hexahydro-2-Methyl-2H-3,6A-Methanobenzofuro(2,3-C)Azocin-10-Ol
CAS No.	100448-10-0
Molecular Formula	C16H19NO2
Molecular Weight	257.33 g/mol
Synonyms	2-Methyl-2H-3,6a-methanobenzofuro[2,3-c]azocin-10-ol, 1,3,4,5,6,11a-hexahydro-; 10-Hydroxy-2-methyl-1,3,4,5,6,11a-hexahydro-2H-3,6a-methanobenzofuro[2,3-c]azocine; Galanthamine intermediate derivative; Bridged benzofuroazocine alkaloid intermediate; Lycorine-type alkaloid precursor
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols suitable for pharmaceutical R&D applications. Every batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We employ validated analytical methods, including HPLC, GC, NMR, and MS, to ensure batch-to-batch consistency and traceability. Quality systems are designed to support development from non-GMP research to GMP-grade material for pre-clinical and clinical studies.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.