Description

n-tert-Butyl-2-thiophenesulfonamide is a specialized organosulfur compound featuring a sulfonamide functional group attached to a thiophene ring. This structure makes it a valuable intermediate and building block in advanced organic synthesis, particularly for the development of pharmaceuticals and agrochemicals. It is primarily sought after by research and development chemists, process development scientists, and manufacturers in the fine chemical and pharmaceutical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides where the thiophene-sulfonamide moiety can impart specific biological activity.
• Material Science Research: Serves as a precursor for developing specialty polymers, ligands for catalysis, and organic electronic materials due to its unique electronic properties.
• Chemical Biology & Proteomics: Employed as a scaffold or tag in the design of enzyme inhibitors, activity-based probes, and molecular tools for studying biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects requiring high-purity, complex intermediates.

Basic Information

Product Name	n-tert-Butyl-2-thiophenesulfonamide
CAS No.	100342-30-1
Molecular Formula	C8H13NO2S2
Molecular Weight	219.32 g/mol
Synonyms	2-Thiophenesulfonamide, N-(1,1-dimethylethyl)-; N-tert-Butylthiophene-2-sulfonamide; tert-Butyl 2-thienylsulfonamide; N-(tert-Butyl)thiophene-2-sulfonamide; 2-(N-tert-Butylsulfamoyl)thiophene; TBTS; N-t-Butyl-2-thiophenesulfonamide
EINECS	Contact for details

Quality Control

Our n-tert-Butyl-2-thiophenesulfonamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We adhere to cGMP principles where applicable to support our clients' regulatory requirements in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.