Description

4-Hydroxyphenylacetic Acid-D6 is a stable isotope-labeled analog of 4-hydroxyphenylacetic acid, where six hydrogen atoms are replaced by deuterium. This high-purity compound is essential as an internal standard in quantitative mass spectrometry, ensuring accurate and reliable analytical results. It is primarily used by researchers and quality control laboratories in the pharmaceutical, biotechnology, and clinical diagnostics industries for precise metabolite quantification and pharmacokinetic studies.

Application

• Internal Standard for LC-MS/MS: Critical for the accurate quantification of 4-hydroxyphenylacetic acid and related metabolites in complex biological matrices like plasma, urine, and tissue samples.
• Pharmaceutical Research & Development: Used in drug metabolism and pharmacokinetic (DMPK) studies to track the absorption, distribution, metabolism, and excretion of drug candidates.
• Clinical Diagnostics: Enables precise measurement of biomarker levels for metabolic disorders, such as tyrosinemia, aiding in disease diagnosis and monitoring.
• Biochemical Research: Serves as a tracer in metabolic pathway analysis to study tyrosine and phenylalanine metabolism in vitro and in vivo.
• Food & Nutritional Science: Applied in research to analyze phenolic acid metabolites derived from dietary polyphenols in human and animal studies.
• Environmental Analysis: Potential use as a labeled standard for detecting phenolic acid contaminants or degradation products in environmental samples.

Basic Information

Item	Detail
Product Name	4-Hydroxyphenylacetic Acid-D6
CAS No.	100287-06-7
Molecular Formula	C8H2D6O3
Molecular Weight	156.19 g/mol
Synonyms	(4-Hydroxyphenyl)acetic-2,2-d2 acid-d4; 2-(4-Hydroxyphenyl)acetic-2,2-d2 acid-d4; p-Hydroxyphenylacetic Acid-D6; 4-Hydroxybenzeneacetic Acid-D6; (p-Hydroxyphenyl)acetic Acid-D6; HPA-d6; 4-HPA-d6; Deuterated 4-Hydroxyphenylacetic Acid
EINECS	Contact for details

Quality Control

Our 4-Hydroxyphenylacetic Acid-D6 is manufactured under strict quality systems to ensure exceptional isotopic purity and chemical integrity, meeting the stringent requirements of analytical reference standards. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (typically ≥98 atom % D), chemical purity (by HPLC), and structural confirmation (by NMR and MS). We support compliance with cGMP and ISO 9001 standards for traceable and reliable material supply.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a cool, dry place. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥98 atom % D
Chemical Purity	≥95% (by NMR)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.