Description

(S)-5-(3,4-Dimethoxybenzyl)-5,6,7,8-Tetrahydro-[1,3]Dioxolo[4,5-G]Isoquinoline is a high-purity chiral isoquinoline derivative, serving as a critical advanced pharmaceutical intermediate. Its value lies in its specific stereochemistry and complex heterocyclic structure, which are essential for synthesizing bioactive molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of new chemical entities, particularly for central nervous system (CNS) and cardiovascular drug discovery programs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel tetrahydroisoquinoline-based alkaloids and active pharmaceutical ingredients (APIs).
• Neurological Research: Used in the research and development of potential therapeutic agents targeting neurological receptors and pathways.
• Asymmetric Synthesis: Employed as a chiral precursor or ligand in stereoselective synthesis due to its defined (S)-configuration.
• Medicinal Chemistry: A versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	(S)-5-(3,4-Dimethoxybenzyl)-5,6,7,8-Tetrahydro-[1,3]Dioxolo[4,5-G]Isoquinoline
CAS No.	19777-79-8
Molecular Formula	C21H23NO4
Molecular Weight	353.41 g/mol
Synonyms	(S)-5-(3,4-Dimethoxybenzyl)-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline; (S)-THIQ derivative; (S)-1-[(3,4-Dimethoxyphenyl)methyl]-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline; (S)-Galanthamine intermediate analog; (S)-Norfumarizine precursor; (S)-Tetrahydropapaverine derivative; (S)-Isoquinoline alkaloid intermediate
EINECS	Contact for details

Quality Control

Our (S)-5-(3,4-Dimethoxybenzyl)-5,6,7,8-Tetrahydro-[1,3]Dioxolo[4,5-G]Isoquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with research and development grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.