Description

2,3,4,5-Tetrahydro-8-(Trifluoromethyl)-1H-Pyrido[4,3-B]Indole is a high-purity, advanced pharmaceutical intermediate characterized by its unique fused heterocyclic structure. This compound is critical for research and development in medicinal chemistry, particularly for synthesizing novel bioactive molecules. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing new therapeutic agents, especially within the central nervous system (CNS) and oncology research fields.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, particularly those targeting neurological receptors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its privileged indole-based scaffold.
• Active Pharmaceutical Ingredient (API) Development: A crucial precursor in the multi-step synthesis of complex APIs, leveraging the trifluoromethyl group for enhanced metabolic stability and lipophilicity.
• Biochemical Tool Compound: Employed in vitro and in vivo to study biological pathways and validate new therapeutic targets.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and process development for clinical trial materials.
• Academic Research: Utilized in university and institutional labs for pioneering research in heterocyclic chemistry and drug discovery.

Basic Information

Product Name	2,3,4,5-Tetrahydro-8-(Trifluoromethyl)-1H-Pyrido[4,3-B]Indole
CAS No.	19735-44-5
Molecular Formula	C₁₂H₁₁F₃N₂
Molecular Weight	240.23 g/mol
Synonyms	8-(Trifluoromethyl)-1,2,3,4-tetrahydro-9H-pyrido[4,3-b]indole; 8-(Trifluoromethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole; 1H-Pyrido[4,3-b]indole, 2,3,4,5-tetrahydro-8-(trifluoromethyl)-; Tetrahydrotrifluoromethylpyridoindole; 19735-44-5; 8-Trifluoromethyl-1,2,3,4-tetrahydro-9H-pyrido[4,3-b]indole; 9H-Pyrido[4,3-b]indole, 8-(trifluoromethyl)-1,2,3,4-tetrahydro-
EINECS	Contact for details

Quality Control

Our 2,3,4,5-Tetrahydro-8-(Trifluoromethyl)-1H-Pyrido[4,3-B]Indole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing all specifications are provided with each shipment, and we support compliance with relevant guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.