Description

Benzene-1,2,3-D3 is a deuterated isotopologue of benzene, specifically labeled at three adjacent positions on the aromatic ring. This compound is essential as a stable, non-radioactive isotopic tracer and a critical building block in advanced organic synthesis and analytical chemistry. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries for mechanistic studies, metabolic pathway elucidation, and the development of deuterated active pharmaceutical ingredients (APIs).

Application

• Deuterated Pharmaceutical Intermediate: A key precursor in the synthesis of deuterium-labeled drug molecules to enhance metabolic stability and pharmacokinetic profiles.
• NMR Spectroscopy Solvent & Standard: Used as an internal standard or solvent in Nuclear Magnetic Resonance (NMR) spectroscopy for structural analysis and quantitative measurements.
• Mechanistic & Metabolic Research: Serves as a tracer in chemical reaction mechanism studies and in-vitro/in-vivo metabolic pathway investigations.
• Material Science Research: Employed in the development of novel organic electronic materials and liquid crystals where isotopic labeling affects physical properties.
• Mass Spectrometry Internal Standard: Acts as a high-purity internal standard for accurate quantification in GC-MS and LC-MS analyses.
• Catalysis & Kinetic Studies: Utilized in catalytic research to study kinetic isotope effects (KIE) and reaction pathways.

Basic Information

Product Name	Benzene-1,2,3-D3
CAS No.	19467-27-7
Molecular Formula	C6H3D3
Molecular Weight	81.12 g/mol
Synonyms	1,2,3-Trideuteriobenzene; Benzene-d3 (1,2,3); [1,2,3-2H3]Benzene; Benzene-1,2,3-d3; 1,2,3-Trideuterobenzene; Perprotiobenzene-1,2,3-D3; (1,2,3-2H3)Benzene; Benzene (1,2,3-D3)
EINECS	Contact for details

Quality Control

Our Benzene-1,2,3-D3 is produced under stringent conditions to ensure high isotopic and chemical purity, meeting the exacting requirements of research and development. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic purity (D atom %), chemical purity, and solvent residues. We adhere to cGMP principles where applicable, and our quality systems are designed to ensure traceability, consistency, and compliance with global regulatory expectations for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are kept upright and sealed when not in use. Keep away from heat, sparks, open flames, and incompatible materials.

Specification

Item	Specification
Appearance	Clear, colorless liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 99.0%
Isotopic Purity (NMR)	≥ 98.0 atom % D (1,2,3-D3)
Water Content (KF)	≤ 0.1%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.