Description

Z-Ser(Tbu)-Osu is a high-purity, protected amino acid derivative widely used as a critical building block in peptide synthesis. This compound is essential for researchers and manufacturers requiring precise control over serine incorporation while preventing unwanted side reactions. It is primarily utilized by the pharmaceutical, biotechnology, and advanced materials sectors for the development of novel therapeutic peptides, APIs, and specialized biomolecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the controlled introduction of serine residues into peptide chains, protecting the hydroxyl group during synthesis.
• Solution-Phase Peptide Synthesis: Used in classical coupling strategies for constructing complex peptide sequences in solution.
• Pharmaceutical Intermediate: Serves as a vital intermediate in the research and production of peptide-based Active Pharmaceutical Ingredients (APIs).
• Bioconjugation: Facilitates the site-specific modification of peptides and proteins for drug delivery systems and diagnostic probes.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive peptide leads.
• Glycopeptide Synthesis: Acts as a precursor for the synthesis of glycopeptides, where serine serves as an attachment point for carbohydrate moieties.

Basic Information

Product Name	Z-Ser(Tbu)-Osu
CAS No.	19460-97-0
Molecular Formula	C19H26N2O7
Molecular Weight	394.42 g/mol
Synonyms	Nα-Carbobenzyloxy-O-tert-butyl-L-serine N-hydroxysuccinimide ester; Z-O-tert-butyl-L-serine N-succinimidyl ester; Z-Ser(OtBu)-OSu; Cbz-Ser(OtBu)-OSu; N-Cbz-O-tert-butyl-L-serine succinimidyl ester; Benzyloxycarbonyl-O-tert-butyl-L-serine N-hydroxysuccinimide ester; Nα-Z-O-tert-butyl-L-serine N-succinimidyl ester
EINECS	Contact for details

Quality Control

Our Z-Ser(Tbu)-Osu is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Optical Rotation	[α]D20: Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.