Description

2-Amino-4-(trifluoromethyl)thiophenol (3-Amino-4-mercaptobenzotrifluoride) is a high-value, multi-functional aromatic building block featuring both an amino and a thiol (mercapto) group on a trifluoromethylated benzene ring. This compound matters for its unique reactivity, enabling its use as a critical intermediate in the synthesis of advanced materials and pharmaceuticals. It is primarily needed by R&D chemists and process engineers in the agrochemical, pharmaceutical, and specialty chemical industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: Key precursor for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring trifluoromethyl and sulfur-containing motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the CF3 group contributes to lipophilicity and biological activity.
• Ligand and Catalyst Development: Serves as a chelating agent or precursor for metal-organic frameworks (MOFs) and homogeneous catalysts due to its amino-thiol functionality.
• Polymer and Material Science: Acts as a monomer or cross-linking agent for specialty polymers, resins, and functional coatings with specific optical or electronic properties.
• Chemical Research & Development: A versatile reagent for organic synthesis, enabling the introduction of sulfur and fluorine atoms into target molecules for structure-activity relationship (SAR) studies.

Basic Information

Product Name	2-Amino-4-(trifluoromethyl)thiophenol / 3-Amino-4-mercaptobenzotrifluoride
CAS No.	19406-49-6
Molecular Formula	C7H6F3NS
Molecular Weight	193.19 g/mol
Synonyms	3-Amino-4-mercaptobenzotrifluoride; 2-Amino-α,α,α-trifluoro-p-toluenethiol; 4-(Trifluoromethyl)-2-aminobenzenethiol; 2-Amino-4-(trifluoromethyl)benzenethiol; Benzenethiol, 2-amino-4-(trifluoromethyl)-; 3-Amino-4-trifluoromethylthiophenol; 4-Trifluoromethyl-2-aminothiophenol
EINECS	Contact for details

Quality Control

Our 2-Amino-4-(trifluoromethyl)thiophenol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. This material is easily oxidized and light-sensitive; prolonged exposure to air, moisture, or light should be avoided.

Specification

Item	Specification
Appearance	White to light yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.