Description

(S)-2-Amino-3-(6-Fluoro-1H-Indol-3-Yl)-Propionic Acid is a non-natural, fluorinated derivative of the essential amino acid tryptophan, characterized by its chiral (S)-configuration and a fluorine atom at the 6-position of the indole ring. This specific structural modification makes it a high-value building block in advanced pharmaceutical research and development. It is primarily utilized by pharmaceutical companies, biotechnology firms, and contract research organizations (CROs) engaged in the synthesis of novel therapeutic agents, particularly in the fields of neurology and oncology.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the synthesis of novel drug candidates targeting neurological disorders and cancer.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate a fluorinated tryptophan analog, modifying peptide stability, bioavailability, and receptor binding affinity.
• Proteomics & Biochemical Research: Serves as a tool compound for studying enzyme-substrate interactions, protein folding, and metabolic pathways where fluorinated amino acids act as probes.
• Radiopharmaceuticals: Potential precursor for the development of fluorine-18 (18F) labeled tracers for Positron Emission Tomography (PET) imaging.
• Agrochemical Research: Investigated as a component in the design of novel, bioactive molecules with potential herbicidal or fungicidal properties.
• Academic Research: Employed in university and institutional labs for fundamental research in medicinal chemistry and organic synthesis methodologies.

Basic Information

Item	Details
Product Name	(S)-2-Amino-3-(6-Fluoro-1H-Indol-3-Yl)-Propionic Acid
CAS No.	19310-00-0
Molecular Formula	C11H11FN2O2
Molecular Weight	222.22 g/mol
Synonyms	(S)-6-Fluorotryptophan; (S)-6-F-Trp; F6-Trp; (S)-2-Amino-3-(6-fluoroindol-3-yl)propanoic acid; (S)-α-Amino-1H-indole-3-propanoic acid, 6-fluoro-; (3S)-2-Amino-3-(6-fluoro-1H-indol-3-yl)propanoic acid; 6-Fluoro-L-tryptophan; L-6-Fluorotryptophan
EINECS	Contact for details

Quality Control

Our (S)-2-Amino-3-(6-Fluoro-1H-Indol-3-Yl)-Propionic Acid is produced under strict quality management systems. Every batch undergoes rigorous analytical testing including HPLC for purity and chiral purity, NMR, and MS for structural confirmation to ensure compliance with research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.