Description

3,4-Difluorothiophene is a high-purity fluorinated heterocyclic building block essential for advanced organic synthesis. This compound is valued for its role in modifying the electronic and physical properties of target molecules, enabling the development of novel materials and active ingredients. It is primarily sought by R&D and production teams in the pharmaceutical, agrochemical, and specialty materials industries for creating sophisticated chemical architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluorothiophene moiety can enhance biological activity and environmental stability.
• Organic Electronic Materials: Serves as a precursor for conjugated polymers and small molecules used in organic light-emitting diodes (OLEDs), organic photovoltaics (OPVs), and field-effect transistors (OFETs).
• Ligand and Catalyst Development: Employed in the synthesis of novel ligands for catalysis and metal-organic frameworks (MOFs), leveraging its electron-withdrawing character.
• Fluorinated Liquid Crystal Research: Acts as a core component in the design of new fluorinated mesogens for display technologies.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis projects requiring the introduction of a fluorinated thiophene ring system.

Basic Information

Product Name	3,4-Difluorothiophene
CAS No.	19259-15-5
Molecular Formula	C4H2F2S
Molecular Weight	120.12 g/mol
Synonyms	3,4-Difluorothiophene; Thiophene, 3,4-difluoro-; 3,4-Difluoro-thiophene; 3,4-Difluorothiofuran; 19259-15-5; NSC 406908; AI3-52789; 3,4-Difluoro-1-thia-2,4-cyclopentadiene
EINECS	Contact for details

Quality Control

Our 3,4-Difluorothiophene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, assay, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.