Description

2,5-Difluorothiophene is a versatile fluorinated heterocyclic building block essential for advanced organic synthesis. This compound matters for its role in introducing fluorine atoms and the thiophene scaffold into target molecules, enabling the fine-tuning of electronic properties, lipophilicity, and metabolic stability. It is primarily needed by researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms enhance biological activity and environmental stability.
• Organic Electronic Materials: Serves as a precursor for conjugated polymers and small molecules used in organic light-emitting diodes (OLEDs), field-effect transistors (OFETs), and solar cells.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Research: A valuable substrate for studying nucleophilic aromatic substitution and other fluorination reactions in academic and industrial R&D settings.
• Liquid Crystal and Advanced Polymer Synthesis: Incorporated into the core structure of liquid crystals and high-performance polymers to modify their mesomorphic and physical properties.

Basic Information

Product Name	2,5-Difluorothiophene
CAS No.	19259-14-4
Molecular Formula	C4H2F2S
Molecular Weight	120.12 g/mol
Synonyms	2,5-Difluorothiophene; Thiophene, 2,5-difluoro-; 2,5-Difluoro-thiophene; 2,5-Difluorothiofuran; 2,5-Difluorothiophen; 2,5-Difluoro-1-thia-2,4-cyclopentadiene; 2,5-Difluoro-1-thia-2,4-cyclopentadiene
EINECS	Contact for details

Quality Control

Our 2,5-Difluorothiophene is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, keep containers tightly sealed and handle in a fume hood. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.