Description

2,3-Difluorothiophene is a high-value fluorinated heterocyclic building block, essential for introducing the thiophene core with fluorine substitution into advanced molecular architectures. Its primary commercial value lies in enabling the synthesis of novel materials and active pharmaceutical ingredients (APIs) with tailored electronic and physicochemical properties. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and organic electronics industries.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in central nervous system (CNS) and antiviral therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluorothiophene moiety can enhance biological activity and metabolic stability.
• Organic Semiconductor Precursor: Serves as a fundamental building block for π-conjugated systems in organic light-emitting diodes (OLEDs), organic field-effect transistors (OFETs), and photovoltaic materials.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorinated Liquid Crystal Research: Acts as a core component in the design of fluorinated liquid crystals for advanced display technologies.
• Custom Synthesis and Contract Manufacturing: Supplied to fine chemical companies for use in custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	2,3-Difluorothiophene
CAS No.	19259-12-2
Molecular Formula	C4H2F2S
Molecular Weight	120.12 g/mol
Synonyms	2,3-Difluorothiophene; Thiophene, 2,3-difluoro-; 2,3-Difluoro-thiophene; 2,3-Difluorothiofuran; 19259-12-2; NSC 406915; AI3-52740; 2,3-Difluorothiophene (stabilized)
EINECS	Contact for details

Quality Control

Our 2,3-Difluorothiophene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place, away from heat and ignition sources. Due to its highly volatile nature, ensure containers are kept tightly sealed and upright. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.