Description

Arachidonic Acid Methyl Ester-D8 is a stable isotope-labeled analog of arachidonic acid methyl ester, where eight hydrogen atoms are replaced by deuterium. This compound is essential as an internal standard in quantitative mass spectrometry, providing unmatched accuracy for tracing and measuring endogenous eicosanoids and related metabolites. It is a critical reagent for researchers and quality control laboratories in the pharmaceutical, biotechnology, and clinical diagnostics sectors, enabling precise lipidomic and metabolomic studies.

Application

• Internal Standard for LC-MS/MS: Primary use as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for arachidonic acid pathway analysis.
• Biomedical Research: Tracing metabolic flux in studies of inflammation, signal transduction, and lipid biochemistry.
• Pharmaceutical Development: Used in pharmacokinetic and pharmacodynamic studies to quantify drug effects on eicosanoid biosynthesis.
• Clinical Diagnostics: Enables accurate measurement of eicosanoids in biological samples for disease biomarker discovery and validation.
• Nutritional Science: Investigating the metabolism of polyunsaturated fatty acids and their impact on health.
• Quality Control & Method Validation: Critical for developing and validating robust analytical methods in contract research organizations (CROs) and testing labs.

Basic Information

Product Name	Arachidonic Acid Methyl Ester-D8
CAS No.	19245-55-7
Molecular Formula	C21H26D8O2
Molecular Weight	326.53 g/mol (for C21H26D8O2)
Synonyms	Methyl arachidonate-d8; All-cis-5,8,11,14-Eicosatetraenoic Acid Methyl Ester-d8; Arachidonic Acid-d8 Methyl Ester; Methyl 5,8,11,14-Eicosatetraenoate-d8; AA-d8 Methyl Ester; Deuterated Arachidonic Acid Methyl Ester; [5,6,8,9,11,12,14,15-2H8]-Arachidonic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our Arachidonic Acid Methyl Ester-D8 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment, chemical purity, and solvent content. We adhere to relevant industry standards for high-purity reference materials to ensure reliable and reproducible performance in your sensitive analytical methods.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. For long-term storage, keep the sealed vial in a desiccator to protect from moisture. Allow the product to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98%
Isotopic Enrichment	≥ 98 atom % D
Isotopic Purity (MS)	≥ 99% D8
Solvent Content (Residual Solvents)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.