Description

p-Toluic-D3 Acid CAS NO 19215-16-8 is a deuterated isotopologue of p-toluic acid, where three hydrogen atoms are replaced by deuterium, a stable hydrogen isotope. This deuteration is critical for applications requiring enhanced analytical precision and metabolic stability studies. It is an essential building block and internal standard for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors.

Application

• Pharmaceutical Research & Development: Serves as a stable isotope-labeled internal standard for the accurate quantification of p-toluic acid and related metabolites in bioanalytical methods like LC-MS/MS.
• Metabolic Pathway Tracing: Used in drug metabolism and pharmacokinetics (DMPK) studies to track the fate of compounds without interference from endogenous substances.
• Agrochemical Analysis: Employed as a reference standard in the environmental and residue analysis of pesticides and herbicides that degrade to or contain toluic acid moieties.
• Organic Synthesis Intermediate: Acts as a deuterated precursor for synthesizing more complex labeled compounds for research in medicinal chemistry and material science.
• NMR Spectroscopy Solvent & Reagent: Useful as a probe or shift reagent in nuclear magnetic resonance (NMR) spectroscopy due to its distinct spectral properties.
• Quality Control & Regulatory Compliance: Provides a certified reference material for ensuring accuracy and meeting regulatory requirements in analytical laboratories.

Basic Information

Product Name	p-Toluic-D3 Acid
CAS No.	19215-16-8
Molecular Formula	C8D3HO2
Molecular Weight	141.17 g/mol
Synonyms	4-Methylbenzoic-2,3,5,6-d4 Acid; 4-Methyl-d3-benzoic Acid; Deutero-p-toluic Acid; p-Toluic Acid-d3; 4-(Trideuteriomethyl)benzoic Acid; 2,3,5,6-Tetradeutero-4-methylbenzoic Acid; Benzoic Acid, 4-(methyl-d3)-; 19215-16-8
EINECS	Contact for details

Quality Control

Every batch of p-Toluic-D3 Acid is produced and analyzed under strict quality management protocols. We provide comprehensive analytical data including isotopic purity (D-content) and chemical purity determined by advanced techniques such as NMR, HPLC, and MS. A detailed Certificate of Analysis (COA) is supplied with each shipment, ensuring traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (NMR/MS)	≥ 98 atom % D
Chemical Purity (Titration)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.