Description

Cyclopropane-1-D1-Carboxylic Acid CAS NO 19136-94-8 is a deuterium-labeled derivative of cyclopropanecarboxylic acid, serving as a crucial stable isotope-labeled building block in advanced chemical synthesis. This compound is essential for creating isotopically labeled molecules used in mechanistic studies, metabolic research, and as internal standards in quantitative mass spectrometry. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and analytical chemistry industries who require high-purity, site-specific deuterium incorporation.

Application

• Pharmaceutical Research & Development: Used as a deuterated synthon in the preparation of isotopically labeled drug candidates for pharmacokinetic (PK), pharmacodynamic (PD), and absorption, distribution, metabolism, and excretion (ADME) studies.
• Metabolic Pathway Tracing: Acts as a tracer in biochemical research to elucidate metabolic pathways and mechanisms of action due to its stable isotopic label.
• Mass Spectrometry Internal Standards: Employed in the synthesis of certified reference materials and internal standards for accurate quantification using LC-MS and GC-MS techniques.
• Agrochemical Development: Utilized in creating labeled analogs of pesticides or herbicides for environmental fate and degradation studies.
• Mechanistic Organic Chemistry: Serves as a probe in kinetic isotope effect (KIE) studies to investigate reaction mechanisms and transition states.
• Material Science Research: Potential use in the synthesis of novel deuterated polymers or organic electronic materials where specific hydrogen-deuterium substitution is required.

Basic Information

Product Name	Cyclopropane-1-D1-Carboxylic Acid
CAS No.	19136-94-8
Molecular Formula	C4H5DO2
Molecular Weight	87.10 g/mol
Synonyms	Cyclopropanecarboxylic-1-d acid; (D)Cyclopropanecarboxylic acid; 1-Deuteriocyclopropanecarboxylic acid; Cyclopropanecarboxylic acid-d1; Cyclopropanecarboxylic acid (1-D); Deuteriocyclopropanecarboxylic acid; Cyclopropane-1-d-carboxylic acid; 1-Deuterocyclopropanecarboxylic acid
EINECS	Contact for details

Quality Control

Our Cyclopropane-1-D1-Carboxylic Acid is manufactured under strict quality control protocols to ensure high isotopic and chemical purity, critical for sensitive research applications. Each batch is analyzed by NMR (¹H, ¹³C, and ²H), mass spectrometry, and HPLC to confirm identity, deuterium incorporation, and purity. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (typically >98 atom % D), chemical purity, and analytical results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation from moisture absorption. For long-term storage, consider storing under an inert gas blanket.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Deuterium Content (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.