Description

2-Methylpropionic-2-D1 Acid CAS NO 19136-93-7 is a deuterium-labeled isotopologue of isobutyric acid, where a single deuterium atom replaces hydrogen at the 2-position, serving as a critical stable isotope-labeled internal standard. This compound is essential for ensuring analytical accuracy and reliability in quantitative mass spectrometry and NMR spectroscopy. It is primarily required by research institutions, pharmaceutical developers, and analytical laboratories engaged in metabolic studies, pharmacokinetics, and precise chemical analysis.

Application

• Internal Standard for Quantitative Analysis: Used as a stable isotope-labeled reference standard in GC-MS and LC-MS for the accurate quantification of isobutyric acid and related metabolites in complex biological matrices.
• Metabolic Pathway Tracing: A vital tool in biomedical and biochemical research for tracing and elucidating metabolic pathways and mechanisms using deuterium as a non-radioactive tracer.
• Pharmaceutical Development: Employed in drug metabolism and pharmacokinetics (DMPK) studies to understand the absorption, distribution, metabolism, and excretion (ADME) of candidate drugs.
• NMR Spectroscopy: Serves as a deuterated standard or shift reference in nuclear magnetic resonance spectroscopy to aid in structural elucidation and purity assessment.
• Chemical Synthesis Intermediate: Used in specialized synthetic chemistry where the introduction of a deuterium label is required for mechanistic studies or to create other labeled compounds.
• Quality Control & Method Validation: Critical for developing and validating robust analytical methods in quality control laboratories, ensuring compliance with regulatory standards.

Basic Information

Product Name	2-Methylpropionic-2-D1 Acid
CAS No.	19136-93-7
Molecular Formula	C4H7DO2
Molecular Weight	89.11 g/mol
Synonyms	Isobutyric-2-d Acid; (2-D)Isobutyric Acid; 2-Deutero-2-methylpropanoic Acid; 2-Methylpropanoic-2-d Acid; Deuterated Isobutyric Acid; Isobutyric Acid-d1; 2-Deuterio-2-methylpropionic Acid; DL-Isobutyric-2-d Acid
EINECS	Contact for details

Quality Control

Our 2-Methylpropionic-2-D1 Acid is manufactured under strict quality systems to ensure high chemical and isotopic purity, critical for research and analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as assay, isotopic enrichment, and impurity profile. We adhere to relevant industry standards and can provide material tailored to specific customer requirements for method validation and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its nature as a strong acid/organic solvent and high volatility, ensure containers are securely sealed and stored away from heat, sparks, and incompatible materials such as strong bases and oxidizers.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.