Description

2-(Iodomethyl)-5-Methyltetrahydrofuran is a versatile halogenated heterocyclic building block of significant interest in advanced organic synthesis. Its value lies in the reactive iodomethyl group, which facilitates efficient carbon-carbon bond formation and functional group transformations under mild conditions. This compound is primarily sought by researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of antiviral and central nervous system (CNS) agents.
• Agrochemical Synthesis: Used in the preparation of advanced herbicides, fungicides, and plant growth regulators requiring specific heterocyclic motifs.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic materials with tailored properties.
• Cross-Coupling Reactions: Acts as an efficient electrophile in various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to introduce complex tetrahydrofuran-containing fragments.
• Natural Product Analog Synthesis: Utilized in the semi-synthesis or total synthesis of natural products and their analogs that contain modified tetrahydrofuran rings.

Basic Information

Product Name	2-(Iodomethyl)-5-Methyltetrahydrofuran
CAS No.	19056-49-6
Molecular Formula	C6H11IO
Molecular Weight	226.06 g/mol
Synonyms	5-Methyl-2-(iodomethyl)tetrahydrofuran; 2-Iodomethyl-5-methyltetrahydrofuran; (5-Methyltetrahydrofuran-2-yl)methyl iodide; Tetrahydro-5-methyl-2-furanmethyl iodide; α-Iodo-5-methyltetrahydrofurfuryl; Iodomethyl methyltetrahydrofuran; 19056-49-6
EINECS	Contact for details

Quality Control

Our 2-(Iodomethyl)-5-Methyltetrahydrofuran is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and transfers should be minimized under direct light.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.