Description

(S)-1,2,3,4-Tetrahydroisoquinoline-3-Methanol CAS NO 18881-17-9 is a high-value, chiral intermediate of significant importance in modern synthetic organic chemistry and pharmaceutical development. Its core value lies in its utility as a key building block for constructing complex molecules with defined stereochemistry, which is critical for the efficacy of many active pharmaceutical ingredients (APIs). This compound is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for applications in asymmetric synthesis and drug discovery.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of various bioactive molecules and potential drug candidates, particularly those targeting neurological and cardiovascular systems.
• Asymmetric Catalyst Ligand Precursor: Used in the development and preparation of chiral ligands for metal-catalyzed asymmetric reactions, enabling the production of enantiomerically pure compounds.
• Agrochemical Synthesis: Serves as a building block for creating novel, stereospecific pesticides and herbicides with enhanced activity and selectivity.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances where precise stereocontrol is required.
• Academic & Industrial Research: A valuable tool in medicinal chemistry programs for structure-activity relationship (SAR) studies and the exploration of new chemical entities.

Basic Information

Product Name	(S)-1,2,3,4-Tetrahydroisoquinoline-3-Methanol
CAS No.	18881-17-9
Molecular Formula	C10H13NO
Molecular Weight	163.22 g/mol
Synonyms	(S)-1,2,3,4-Tetrahydro-3-isoquinolinemethanol; (S)-TIHM; (S)-1,2,3,4-Tetrahydroisoquinoline-3-carbinol; (3S)-1,2,3,4-Tetrahydroisoquinoline-3-methanol; (S)-(-)-1,2,3,4-Tetrahydroisoquinoline-3-methanol; (S)-TIQM; (S)-3-(Hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline
EINECS	Contact for details

Quality Control

Our (S)-1,2,3,4-Tetrahydroisoquinoline-3-Methanol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity (assay), chiral excess, and impurity profile is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.