Description

3-Bromo-1-Butyne is a versatile halogenated alkyne building block essential for advanced organic synthesis. Its terminal alkyne and bromine functionalities make it a critical reagent for constructing complex molecular architectures via cross-coupling and cycloaddition reactions. This high-purity intermediate is primarily sought by pharmaceutical R&D laboratories, agrochemical manufacturers, and specialty chemical companies for developing active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for creating complex heterocycles and targeted molecular scaffolds.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators requiring specific alkyne motifs.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialized polymers and advanced organic electronic materials.
• Cross-Coupling Reactions: An essential substrate for Sonogashira, Heck, and other palladium-catalyzed coupling reactions to form carbon-carbon bonds.
• Click Chemistry: Utilized in Huisgen 1,3-dipolar cycloaddition (azide-alkyne cycloaddition) for bioconjugation and polymer labeling applications.
• Ligand & Catalyst Development: Employed in the synthesis of novel phosphine and N-heterocyclic carbene (NHC) ligands for asymmetric catalysis.

Basic Information

Product Name	3-Bromo-1-Butyne
CAS No.	18868-72-9
Molecular Formula	C4H5Br
Molecular Weight	132.99 g/mol
Synonyms	1-Butyne, 3-bromo-; 3-Butyn-1-yl bromide; 3-Bromobut-1-yne; Bromomethylacetylene; 1-Bromo-3-butyne; 3-Bromobutyne; 3-Bromo-1-butyne; 3-Butynyl bromide
EINECS	242-638-9

Quality Control

Our 3-Bromo-1-Butyne is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to verify identity, potency, and impurity profiles. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials. Due to its highly volatile and reactive nature, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) at temperatures between 2°C and 8°C for long-term stability. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Purity (HPLC)	≥ 96.0%
Water Content (KF)	≤ 0.5%
Density	~1.40 g/cm³
Boiling Point	~110-115 °C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.