Description

4-Amino-4-Phosphonobutyric Acid is a specialized phosphonic acid derivative that serves as a potent and selective antagonist of the NMDA (N-methyl-D-aspartate) receptor. This compound is a critical research tool in neuroscience and pharmacology for studying excitatory neurotransmission, neuronal plasticity, and neurotoxicity. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on neurological disorders, pain management, and neuroprotective agent development.

Application

• Neuroscience Research: A key pharmacological agent for studying NMDA receptor function, synaptic transmission, and long-term potentiation (LTP).
• Drug Discovery & Development: Used as a reference standard and lead compound in the development of novel neuroprotective agents, analgesics, and treatments for stroke and neurodegenerative diseases.
• Biochemical Assays: Employed in in vitro and cellular assays to selectively block NMDA receptor channels and study calcium influx and excitotoxicity.
• Academic & Clinical Research: Fundamental for investigating the role of glutamate receptors in learning, memory, and various neurological pathologies.
• Chemical Synthesis: Serves as a versatile synthetic intermediate for preparing more complex phosphonate-containing molecules with potential biological activity.

Basic Information

Product Name	4-Amino-4-Phosphonobutyric Acid
CAS No.	18865-31-1
Molecular Formula	C4H10NO5P
Molecular Weight	183.10 g/mol
Synonyms	AP4; APB; DL-AP4; 4-Amino-4-phosphonobutanoic acid; (RS)-2-Amino-4-phosphonobutanoic acid; (±)-2-Amino-4-phosphonobutanoic acid; DL-2-Amino-4-phosphonobutanoate; NMDA receptor antagonist AP4
EINECS	Contact for details

Quality Control

Our 4-Amino-4-Phosphonobutyric Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and specification compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccants or storage under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.