Description

L-Alanine-D4 is a stable isotope-labeled analog of the essential amino acid L-Alanine, where four hydrogen atoms are replaced by deuterium. This high-purity compound is critical for advanced research requiring precise metabolic and pharmacokinetic tracing. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors for applications such as mass spectrometry and NMR spectroscopy.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a quantitative reference standard in LC-MS and GC-MS analyses for accurate measurement of endogenous L-alanine levels in complex biological matrices.
• Metabolic Pathway Tracing: Used in deuterium-labeling studies to investigate amino acid metabolism, protein synthesis rates, and metabolic flux in cell cultures, tissues, and whole organisms.
• NMR Spectroscopy: Acts as a valuable probe in nuclear magnetic resonance studies due to the distinct magnetic properties of deuterium, aiding in structural and dynamic analysis of biomolecules.
• Pharmaceutical Research & Development: Employed in the development and validation of bioanalytical methods for new drug candidates, ensuring precise pharmacokinetic and metabolomic data.
• Stable Isotope-Labeled Compound Synthesis: Functions as a key building block for the synthesis of more complex deuterated peptides, proteins, or other biochemicals.
• Nutritional and Clinical Research: Applied in studies examining amino acid turnover, nutritional status, and metabolic disorders to gain insights into human physiology and disease.

Basic Information

Product Name	L-Alanine-D4
CAS No.	18806-29-6
Molecular Formula	C₃H₃D₄NO₂
Molecular Weight	93.11 g/mol
Synonyms	(2S)-2-Aminopropanoic-3,3,3-d3 acid; L-2-Aminopropionic-3,3,3-d3 acid; (S)-Alanine-3,3,3-d3; L-α-Alanine-d4; Deuterated L-Alanine; L-Alanine (tetradeutero); Alanine-d4; (S)-(+)-Alanine-3,3,3-d3
EINECS	Contact for details

Quality Control

Our L-Alanine-D4 is manufactured under strict quality systems to ensure exceptional isotopic and chemical purity, which is paramount for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing specifications for isotopic enrichment, chemical purity, and absence of critical impurities. We adhere to relevant industry standards for stable isotope-labeled compounds to guarantee reliable and reproducible performance in your research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccated conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Enrichment	≥ 98 atom % D
Assay (HPLC)	≥ 98.0%
Optical Rotation	+13.5° to +15.5° (c=1 in H₂O)
Chemical Purity	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.