Description

4'-(Trimethylsilyloxy)Acetophenone CAS NO 18803-29-7 is a specialized organosilicon compound featuring a trimethylsilyl-protected phenolic hydroxyl group. This chemical serves as a valuable protected intermediate and building block in advanced organic synthesis, enabling precise control over reaction pathways. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and fine chemical industries for the production of complex molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring phenolic protection strategies.
• Organic Synthesis Reagent: Used as a protected precursor for the preparation of various acetophenone derivatives and other aromatic compounds.
• Ligand and Catalyst Development: Serves as a starting material for creating novel ligands and organometallic catalysts in asymmetric synthesis.
• Material Science Research: Employed in the development of advanced organic materials, including monomers for specialty polymers.
• Agrochemical Synthesis: Intermediate in the research and production of certain herbicides and plant growth regulators.
• Academic & Industrial R&D: A versatile reagent for methodological studies in synthetic organic chemistry laboratories.

Basic Information

Product Name	4'-(Trimethylsilyloxy)Acetophenone
CAS No.	18803-29-7
Molecular Formula	C11H16O2Si
Molecular Weight	208.33 g/mol
Synonyms	1-[4-(Trimethylsilyloxy)phenyl]ethanone; 4-Acetylphenyl trimethylsilyl ether; p-(Trimethylsilyloxy)acetophenone; 4-Acetophenone trimethylsilyl ether; 4-Hydroxyacetophenone trimethylsilyl ether; TMS-protected 4-hydroxyacetophenone; 4-Acetylphenol TMS ether
EINECS	Contact for details

Quality Control

Our production of 4'-(Trimethylsilyloxy)Acetophenone adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for your synthetic processes. Each lot undergoes comprehensive analysis using techniques including HPLC, GC, and NMR spectroscopy. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We are committed to meeting the exacting standards required for research and cGMP manufacturing applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container should be kept tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.