Description

4-Chloro-3-Trifluoromethyl-Benzenethiol is a specialized organosulfur building block characterized by a reactive thiol (-SH) group and a chloro-trifluoromethyl substituted aromatic ring. This unique structure makes it a valuable intermediate for synthesizing complex molecules where the introduction of sulfur and fluorine functionalities is critical. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for applications in drug discovery, crop protection, and advanced material science.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring thioether linkages or fluorinated aromatic systems.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Ligand and Catalyst Precursor: Serves as a starting material for creating specialized ligands used in transition metal catalysis and coordination chemistry.
• Polymer Modification: Employed to introduce thiol functional groups into polymer chains for cross-linking, adhesion promotion, or creating specialty polymers.
• Material Science Research: Utilized in the development of novel organic electronic materials, liquid crystals, and self-assembled monolayers (SAMs).
• Chemical Derivatization: Acts as a versatile reagent for the functionalization of other molecules via nucleophilic substitution or addition reactions.

Basic Information

Product Name	4-Chloro-3-Trifluoromethyl-Benzenethiol
CAS No.	18800-22-1
Molecular Formula	C7H4ClF3S
Molecular Weight	212.62 g/mol
Synonyms	4-Chloro-α,α,α-trifluoro-m-toluenethiol; 4-Chloro-3-(trifluoromethyl)benzenethiol; 4-Chloro-α,α,α-trifluoro-3-methylbenzenethiol; 3-Trifluoromethyl-4-chlorobenzenethiol; 4-Chloro-3-trifluoromethylthiophenol; 2-Chloro-5-mercaptobenzotrifluoride; (4-Chloro-3-(trifluoromethyl)phenyl)thiol; m-Trifluoromethyl-p-chlorothiophenol
EINECS	Contact for details

Quality Control

Our production of 4-Chloro-3-Trifluoromethyl-Benzenethiol adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including GC, HPLC, and NMR to confirm identity and quantify purity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C) under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. Keep away from strong oxidizing agents, strong bases, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.