Description

2-Bromo-4-Cyanothiophene is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound matters for its unique reactivity profile, where the bromine and cyano substituents on the thiophene ring serve as orthogonal handles for sequential cross-coupling and functional group transformations. It is critically needed by research chemists and process development teams in the pharmaceutical, agrochemical, and materials science industries to construct complex molecules for active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of new-generation herbicides and fungicides, leveraging the thiophene scaffold for bioactivity.
• Organic Electronic Materials: Serves as a fundamental building block for π-conjugated systems in organic semiconductors, OLEDs, and solar cell materials.
• Ligand and Catalyst Development: Employed to create sophisticated ligands for transition metal catalysis, enabling challenging chemical transformations.
• Polymer Chemistry: Incorporated as a monomer or functionalizing agent to produce specialty polymers with tailored electronic or optical properties.
• Chemical Research & Development: A versatile reagent for method development in cross-coupling reactions (e.g., Suzuki, Stille, Negishi) and heterocyclic chemistry.

Basic Information

Product Name	2-Bromo-4-Cyanothiophene
CAS No.	18792-00-2
Molecular Formula	C5H2BrNS
Molecular Weight	188.04 g/mol
Synonyms	4-Cyano-2-bromothiophene; 2-Bromo-4-thiophenecarbonitrile; 2-Bromothiophene-4-carbonitrile; Thiophene, 2-bromo-4-cyano-; 18792-00-2; 2-Bromo-4-cyanothiophene; 2-Bromothiophene-4-carbonitrile
EINECS	Contact for details

Quality Control

Every batch of our 2-Bromo-4-Cyanothiophene is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light) and hygroscopic (moisture-sensitive); ensure containers are sealed under an inert atmosphere after opening to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	68 - 72 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.