Description

4-Bromothiophene-2-Carbonitrile is a versatile brominated heterocyclic building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both a bromine substituent and a nitrile group on a thiophene core, makes it a critical intermediate for constructing complex molecules. This compound is primarily sought after by research institutions and industrial R&D departments engaged in pharmaceutical development, agrochemical research, and materials science.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing functionalized thiophene scaffolds.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the thiophene ring's bioactivity.
• Material Science Research: Acts as a monomer or building block for creating conjugated polymers and organic electronic materials like organic semiconductors and OLED components.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for metal catalysis and organocatalysts due to its electron-withdrawing nitrile group.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological processes.
• Custom Synthesis and Scale-up: A fundamental starting material for contract research organizations (CROs) and CDMOs performing custom synthesis for clients.

Basic Information

Product Name	4-Bromothiophene-2-Carbonitrile
CAS No.	18791-99-6
Molecular Formula	C5H2BrNS
Molecular Weight	188.04 g/mol
Synonyms	2-Cyano-4-bromothiophene; 4-Bromo-2-thiophenecarbonitrile; 4-Bromothiophene-2-carbonitrile; 2-Thiophenecarbonitrile, 4-bromo-; Thiophene-2-carbonitrile, 4-bromo-; 4-Bromothieno[2,3-c]pyridine? (Common mis-assignment, verify structure); 4-Bromo-2-cyanothiophene
EINECS	Contact for details

Quality Control

Every batch of 4-Bromothiophene-2-Carbonitrile is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.