Description

3-Bromothiophene-2-Carbonitrile is a versatile and high-value brominated heterocyclic building block essential for advanced organic synthesis. Its unique structure, featuring both an electron-withdrawing cyano group and a reactive bromine atom, makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and insecticides, leveraging the thiophene scaffold for bioactivity.
• Material Science Building Block: Employed in the creation of organic semiconductors, conductive polymers, and non-linear optical (NLO) materials due to its electron-deficient thiophene core.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in transition metal catalysis and cross-coupling reactions.
• Chemical Research & Development: A fundamental reagent for method development in organic chemistry, including Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Dye and Pigment Intermediate: Utilized in the synthesis of complex heterocyclic dyes and pigments for specialized applications.

Basic Information

Product Name	3-Bromothiophene-2-Carbonitrile
CAS No.	18791-98-5
Molecular Formula	C5H2BrNS
Molecular Weight	188.04 g/mol
Synonyms	2-Cyano-3-bromothiophene; 3-Bromo-2-cyanothiophene; 3-Bromothiophene-2-carbonitrile; 2-Thiophenecarbonitrile, 3-bromo-; Thiophene-2-carbonitrile, 3-bromo-; 3-Bromothieno[2,3-c]pyridine? (Incorrect, but a common mis-search); 3-Bromo-2-thiophenecarbonitrile
EINECS	Contact for details

Quality Control

Every batch of our 3-Bromothiophene-2-Carbonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.