Description

Tris-(2-Methanethiosulfonylethyl)Amine is a specialized organic compound featuring three methanethiosulfonate (MTS) reactive groups linked via an amine core. This structure makes it a highly effective trifunctional crosslinking agent and a key reagent for site-directed spin labeling (SDSL) in protein biochemistry and structural biology research. It is essential for scientists and manufacturers requiring precise, reversible modification of cysteine residues to study protein dynamics, engineer bioconjugates, or develop advanced materials. The compound is primarily utilized in pharmaceutical R&D, academic research institutions, and biotechnology companies focused on protein engineering and diagnostic assay development.

Application

• Site-Directed Spin Labeling (SDSL): A critical reagent for introducing spin labels onto cysteine residues in proteins for Electron Paramagnetic Resonance (EPR) spectroscopy studies of protein structure and dynamics.
• Protein Crosslinking & Conjugation: Acts as a trifunctional crosslinker to create stable protein-protein or protein-ligand complexes, useful in antibody-drug conjugate (ADC) research and biomaterial fabrication.
• Bioconjugation & Protein Engineering: Enables controlled, reversible modification of thiol groups for creating custom bioconjugates, enzyme immobilization, and surface functionalization.
• Structural Biology Tool: Used to probe distances and conformational changes within macromolecular complexes, aiding in the determination of protein tertiary and quaternary structures.
• Diagnostic Reagent Synthesis: Serves as a building block for synthesizing specialized reagents used in immunoassays and other diagnostic platforms.
• Polymer & Material Science: Employed as a functional monomer or crosslinker in the synthesis of smart polymers and hydrogels with responsive properties.

Basic Information

Product Name	Tris-(2-Methanethiosulfonylethyl)Amine
CAS No.	18365-77-0
Molecular Formula	C9H21NO6S6
Molecular Weight	455.68 g/mol
Synonyms	Tris(2-(methylsulfonylthio)ethyl)amine; MTSL Trifunctional Crosslinker; 2,2',2''-Nitrilotris(ethane-1-thiol) tris(methanesulfonothioate); Tris-MTS; Nitrilotris(ethyl methanethiosulfonate); Trifunctional Methanethiosulfonate Reagent; Tris(2-(methanesulfonylthio)ethyl)amine; Tris-MTS Crosslinker
EINECS	Contact for details

Quality Control

Our Tris-(2-Methanethiosulfonylethyl)Amine is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing including HPLC for purity assessment and NMR for structural confirmation. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profile is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and reactivity. Keep the container tightly sealed in a desiccated environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.