Description

2-Methyl-2-[(Trimethylsilyl)Oxy]Propanenitrile is a versatile organosilicon reagent featuring a protected cyanohydrin functionality. This compound is valued for its role as a key synthetic intermediate in the preparation of complex molecules, particularly in pharmaceutical and fine chemical synthesis. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing chiral centers and introducing nitrile groups under mild conditions.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring chiral α-hydroxy nitrile or α-silyloxy nitrile motifs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where its protected functional group allows for selective transformations.
• Fine Chemical Production: Serves as a precursor for specialty chemicals, flavors, and fragrances requiring high-purity intermediates.
• Polymer Chemistry: Employed in the synthesis of specialized monomers and polymers with tailored properties, such as polyacrylonitrile derivatives.
• Academic & Industrial Research: A valuable reagent for methodological development in organic synthesis, including studies on cyanohydrin chemistry and silicon-protecting group strategies.
• Material Science: Potential use in the surface modification of materials and the development of silicon-containing hybrid organic-inorganic compounds.

Basic Information

Item	Details
Product Name	2-Methyl-2-[(Trimethylsilyl)Oxy]Propanenitrile
CAS No.	18296-11-2
Molecular Formula	C7H15NOSi
Molecular Weight	157.29 g/mol
Synonyms	Acetone Cyanohydrin Trimethylsilyl Ether; (Trimethylsilyloxy)isobutyronitrile; 2-Hydroxy-2-methylpropionitrile trimethylsilyl ether; 2-Methyl-2-(trimethylsiloxy)propionitrile; TMS-Cyanohydrin; α-(Trimethylsiloxy)isobutyronitrile; 2-(Trimethylsilyloxy)-2-methylpropanenitrile
EINECS	Contact for details

Quality Control

Our 2-Methyl-2-[(Trimethylsilyl)Oxy]Propanenitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.