Description

(2,2-Dimethylpropoxy)Trimethylsilane is a specialized organosilicon compound, valued for its role as a versatile silylating agent and protected intermediate in advanced organic synthesis. Its primary commercial value lies in its ability to introduce the trimethylsilyl (TMS) group onto alcohols and other nucleophiles, offering enhanced stability and altered reactivity for downstream chemical processes. This product is essential for research and production in the pharmaceutical, agrochemical, and specialty materials sectors, where precise molecular modification is critical.

Application

• Pharmaceutical Intermediate: Used as a protecting group for hydroxyl functionalities during the multi-step synthesis of active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Serves as a key reagent in the production of advanced pesticides and herbicides, where it modifies compound solubility and stability.
• Silicon-Based Polymer Chemistry: Acts as a monomer or modifying agent in the synthesis of specialty silicones and siloxane polymers.
• Surface Modification Agent: Employed to functionalize inorganic surfaces like silica or glass, imparting hydrophobic properties.
• Analytical Chemistry Reagent: Utilized in gas chromatography (GC) and mass spectrometry (MS) for derivatization of polar compounds to improve volatility and detection.
• Cross-Coupling Reactions: Functions as a reagent in palladium-catalyzed and other metal-mediated coupling reactions in fine chemical synthesis.

Basic Information

Product Name	(2,2-Dimethylpropoxy)Trimethylsilane
CAS No.	18246-63-4
Molecular Formula	C8H20OSi
Molecular Weight	160.33 g/mol
Synonyms	Neopentyloxytrimethylsilane; Trimethyl(2,2-dimethylpropoxy)silane; (Neopentyloxy)trimethylsilane; 2,2-Dimethyl-1-(trimethylsilyloxy)propane; 1-(Trimethylsilyloxy)-2,2-dimethylpropane; TMS neopentyl ether; Silane, trimethyl(2,2-dimethylpropoxy)-
EINECS	Contact for details

Quality Control

Our (2,2-Dimethylpropoxy)Trimethylsilane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with internal and customer-specific quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Density (20°C)	0.78 - 0.82 g/mL
Refractive Index (n20D)	1.405 - 1.415

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.