Description

n-(2-Hydroxyethyl)Succinimide is a versatile bifunctional chemical intermediate featuring both a reactive succinimide ring and a terminal hydroxyl group. This unique structure makes it a valuable building block for synthesizing more complex molecules, particularly in the pharmaceutical and specialty chemical sectors. It is primarily sought by research and development teams, process chemists, and manufacturers in the pharmaceutical, agrochemical, and polymer industries for creating active pharmaceutical ingredients (APIs), functionalized polymers, and advanced material precursors.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of various active pharmaceutical ingredients (APIs), particularly those requiring a hydroxylethyl-linked succinimide moiety for enhanced solubility or bioactivity.
• Polymer Modification: Acts as a functional monomer or cross-linking agent for modifying polyesters, polyamides, and polyurethanes, introducing reactive sites for further chemical grafting.
• Bioconjugation Reagent: Used in the development of antibody-drug conjugates (ADCs) and protein-polymer hybrids, where its succinimide group reacts with amine residues under mild conditions.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, and plant growth regulators with tailored properties.
• Cosmetic Ingredient Synthesis: Employed in the production of specialty surfactants and conditioning agents for personal care formulations.
• Cross-linking Agent: Utilized in the formulation of coatings, adhesives, and sealants to improve mechanical strength and chemical resistance.

Basic Information

Product Name	n-(2-Hydroxyethyl)Succinimide
CAS No.	18190-44-8
Molecular Formula	C6H9NO3
Molecular Weight	143.14 g/mol
Synonyms	2-(2,5-Dioxopyrrolidin-1-yl)ethanol; 1-(2-Hydroxyethyl)-2,5-pyrrolidinedione; N-Hydroxyethylsuccinimide; 1-(2-Hydroxyethyl)pyrrolidine-2,5-dione; Succinimidoethanol; HES; 2-Hydroxyethyl succinimide
EINECS	242-080-4

Quality Control

Our n-(2-Hydroxyethyl)Succinimide is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for demanding applications in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed when not in use to prevent absorption of atmospheric moisture, which may affect product quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	95 - 100 °C
Loss on Drying	≤ 0.5%
Heavy Metals (as Pb)	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.