Description

Methyl n-Trimethylsilylcarbamate CAS NO 18147-09-6 is a specialized organosilicon reagent primarily used as a versatile silylating agent and protecting group intermediate in advanced organic synthesis. Its core value lies in enabling the synthesis of complex molecules by facilitating the introduction of the trimethylsilyl (TMS) group under controlled conditions. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries who require high-purity intermediates for sensitive reactions.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing silyl protecting groups.
• Peptide Synthesis: Used as a reagent for the protection of amino groups during solid-phase and solution-phase peptide synthesis.
• Agrochemical Production: Intermediate in the manufacture of advanced crop protection agents and herbicides.
• Material Science Research: Employed in the development of novel silicon-based polymers and hybrid organic-inorganic materials.
• Chemical Derivatization: Utilized in analytical chemistry for the derivatization of compounds containing active hydrogens (e.g., -OH, -NH) for Gas Chromatography (GC) or Mass Spectrometry (MS) analysis.
• Nucleoside & Carbohydrate Chemistry: Acts as a protecting group reagent in the synthesis of modified nucleosides and complex carbohydrates.

Basic Information

Item	Details
Product Name	Methyl n-Trimethylsilylcarbamate
CAS No.	18147-09-6
Molecular Formula	C5H13NO2Si
Molecular Weight	147.25 g/mol
Synonyms	Methyl N-(Trimethylsilyl)carbamate; Carbamic acid, N-(trimethylsilyl)-, methyl ester; Trimethylsilyl Carbamate Methyl Ester; Methyl Trimethylsilylcarbamate; N-Trimethylsilyl Methyl Carbamate; TMS-Carbamate Methyl Ester; NSC 163063
EINECS	Contact for details

Quality Control

Our Methyl n-Trimethylsilylcarbamate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of research and development as well as scale-up production environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.