Description

3-(1-Pyrrolidinylcarbonyl)Coumarin is a specialized organic compound belonging to the coumarin derivative family, recognized for its unique pyrrolidine-carbonyl functionalization. This structural motif makes it a valuable advanced intermediate and pharmacophore building block in synthetic organic chemistry and pharmaceutical research. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting enzyme inhibition or possessing fluorescent properties for bio-imaging.
• Organic Synthesis Building Block: Used in constructing complex heterocyclic frameworks and functionalized coumarin libraries for high-throughput screening.
• Agrochemical Research: Serves as a core structure for developing new generation pesticides and herbicides with specific biological activity.
• Fluorescent Probe Development: Utilized in creating sensitive chemosensors and fluorescent markers due to the inherent photophysical properties of the coumarin core.
• Material Science: Investigated as a monomer or additive for advanced polymeric materials with specific optical or electronic characteristics.
• Academic & Industrial R&D: Essential reagent for methodological studies in organic chemistry, including catalysis and new bond-forming reactions.

Basic Information

Product Name	3-(1-Pyrrolidinylcarbonyl)Coumarin
CAS No.	18144-50-8
Molecular Formula	C₁₄H₁₃NO₃
Molecular Weight	243.26 g/mol
Synonyms	3-(N-Pyrrolidinecarbonyl)coumarin; 3-(Pyrrolidine-1-carbonyl)-2H-chromen-2-one; 2-Oxo-2H-chromene-3-carboxylic acid pyrrolidide; 3-Carbamoylcoumarin, N-pyrrolidinyl-; Coumarin-3-carboxylic acid pyrrolidide; 1-(2-Oxo-2H-chromene-3-carbonyl)pyrrolidine
EINECS	Contact for details

Quality Control

Every batch of our 3-(1-Pyrrolidinylcarbonyl)Coumarin is produced and tested under a strict quality management system. We ensure high purity and batch-to-batch consistency through advanced analytical techniques including HPLC, GC, and NMR. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, and we support customer audits and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound should be kept under an inert atmosphere for long-term storage to maintain stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	158 - 162 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.