Description

2-(Trimethylsilyl)Ethylamine is a versatile organosilicon compound featuring a reactive primary amine group protected by a trimethylsilyl (TMS) moiety. This unique structure makes it a valuable building block and protecting group reagent in advanced organic synthesis, particularly for the pharmaceutical and agrochemical industries. It is essential for researchers and manufacturers developing active pharmaceutical ingredients (APIs), fine chemicals, and specialty materials who require high-purity, reliable intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug molecules, particularly where amine protection and deprotection strategies are required.
• Peptide Synthesis: Used as a protecting group for amines during solid-phase and solution-phase peptide synthesis to prevent unwanted side reactions.
• Agrochemical Production: Serves as a precursor or intermediate in the manufacture of herbicides, fungicides, and other crop protection agents.
• Material Science: Employed in the surface modification of silica and other materials, and as a precursor for silicon-containing polymers and coatings.
• Cross-coupling Reactions: Acts as a reagent in palladium-catalyzed and other metal-mediated coupling reactions to introduce functionalized ethylamine groups.
• Asymmetric Synthesis: Utilized in chiral auxiliaries and catalysts for the production of enantiomerically pure compounds.

Basic Information

Product Name	2-(Trimethylsilyl)Ethylamine
CAS No.	18135-04-1
Molecular Formula	C5H15NSi
Molecular Weight	117.27 g/mol
Synonyms	2-(Trimethylsilyl)ethanamine; (2-Aminoethyl)trimethylsilane; Trimethyl(2-aminoethyl)silane; 2-Trimethylsilylethylamine; TMS-EA; TMS-ethylamine; N-(Trimethylsilyl)ethylamine; Aminoethyltrimethylsilane
EINECS	242-036-6

Quality Control

Our 2-(Trimethylsilyl)Ethylamine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available for all shipments to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.