Description

1-(Trimethylsilyl)Indole is a versatile organosilicon building block used in advanced organic synthesis. This compound is valued for its role as a protected indole derivative, enabling selective functionalization and complex molecule construction. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key protected synthon for the synthesis of indole-based drug candidates, including serotonin receptor modulators and kinase inhibitors.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides that leverage the indole scaffold for biological activity.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of specialty polymers and organic electronic materials.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions like Suzuki, Heck, or Stille couplings for carbon-carbon bond formation.
• Nucleophilic Reagent: Utilizes the silyl-protected nitrogen for regioselective alkylation or acylation reactions under mild conditions.
• Academic & R&D: Employed in research laboratories for methodological development and the exploration of new synthetic pathways in heterocyclic chemistry.

Basic Information

Item	Detail
Product Name	1-(Trimethylsilyl)Indole
CAS No.	17983-42-5
Molecular Formula	C11H15NSi
Molecular Weight	189.33 g/mol
Synonyms	1-(Trimethylsilyl)-1H-indole; N-Trimethylsilylindole; Indole, 1-(trimethylsilyl)-; 1H-Indole, 1-(trimethylsilyl)-; N-(Trimethylsilyl)indole; 1-TMS-indole; TMSI; 1-Trimethylsilylindole
EINECS	Contact for details

Quality Control

Our 1-(Trimethylsilyl)Indole is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.