Description

L-Phenyl-D5-Alanine-2,3,3-D3 is a high-purity, isotopically labeled derivative of the essential amino acid L-phenylalanine, specifically designed for advanced analytical and research applications. This compound is critical for use as an internal standard in mass spectrometry-based quantitative analysis, ensuring unparalleled accuracy and reliability in measurement. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in metabolomics, proteomics, and pharmacokinetic studies.

Application

• Quantitative Mass Spectrometry: Serves as a stable isotope-labeled internal standard for the precise quantification of L-phenylalanine and related metabolites in complex biological matrices like plasma, urine, and tissue samples.
• Pharmacokinetic & Drug Metabolism Studies (DMPK): Essential for tracing drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research, improving data accuracy.
• Metabolomics & Biomarker Discovery: Enables accurate profiling of amino acid pathways to identify disease biomarkers and understand metabolic disorders.
• Proteomics Research: Used in stable isotope labeling by amino acids in cell culture (SILAC) and other techniques for quantitative protein analysis.
• Clinical Diagnostics: Supports the development and validation of high-precision diagnostic assays for conditions like phenylketonuria (PKU).
• Nutritional Science Research: Facilitates studies on protein metabolism, amino acid turnover, and dietary impact in human and animal models.

Basic Information

Product Name	L-Phenyl-D5-Alanine-2,3,3-D3
CAS No.	17942-32-4
Molecular Formula	C9H6D8NO2
Molecular Weight	~171.23 g/mol
Synonyms	(2S)-2-Amino-3-(2,3,4,5,6-pentadeuteriophenyl)propanoic-2,3,3-d3 acid; L-Phenylalanine-d8; L-Phe-d8; (S)-2-Amino-3-(pentadeuteriophenyl)propionic-2,3,3-d3 acid; Phenylalanine-d8; [2H8]-L-Phenylalanine; L-2-Amino-3-(2,3,4,5,6-2H5)phenylpropanoic-2,3,3-2H3 acid
EINECS	Contact for details

Quality Control

Every batch of L-Phenyl-D5-Alanine-2,3,3-D3 is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive research applications. We provide comprehensive Certificates of Analysis (COA) detailing isotopic purity, chemical purity, and specific analytical results from techniques such as NMR, HPLC, and MS. Our quality commitment aligns with the standards expected in pharmaceutical and analytical research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to maintain stability and purity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98 atom % D
Chemical Purity	≥ 95%
Optical Rotation	[α]20/D: -33° to -38° (c=1 in 1N HCl)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.