Description

tert-Butoxychlorodiphenylsilane is a versatile organosilicon reagent primarily used as a silylating agent and a key building block in organic synthesis. Its value lies in its ability to introduce the bulky tert-butoxydiphenylsilyl (TBDPS) protecting group, which offers excellent stability under a wide range of reaction conditions while remaining selectively removable. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise protection of hydroxyl groups during multi-step synthetic sequences.

Application

• Hydroxyl Group Protection: Selective protection of primary and secondary alcohols in complex molecule synthesis, particularly in nucleoside and carbohydrate chemistry.
• Pharmaceutical Intermediate: Key reagent in the synthesis of active pharmaceutical ingredients (APIs) where robust, orthogonal protecting group strategies are required.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides that require silane-modified intermediates.
• Polymer & Material Science: Silylation agent for surface modification of silica, glass, and other inorganic materials to alter surface properties.
• Peptide Synthesis: Protection of serine, threonine, or tyrosine side chains during solid-phase peptide synthesis (SPPS).
• Natural Product Synthesis: Employed in the total synthesis of complex natural products like macrolides and polyketides.
• Chiral Auxiliary & Catalyst Preparation: Building block for creating chiral silane-based ligands and auxiliaries used in asymmetric catalysis.

Basic Information

Product Name	tert-Butoxychlorodiphenylsilane
CAS No.	17922-24-6
Molecular Formula	C₁₆H₁₉ClOSi
Molecular Weight	290.86 g/mol
Synonyms	Chloro(tert-butoxy)diphenylsilane; tert-Butyldiphenylsilyl Chloride; TBDPS-Cl; tert-Butoxychlorodiphenylsilane; (tert-Butoxy)chlorodiphenylsilane; Diphenyl-tert-butoxysilyl Chloride; Silane, chloro(1,1-dimethylethoxy)diphenyl-; Chlorodiphenyl-tert-butoxysilane
EINECS	Contact for details

Quality Control

Our tert-Butoxychlorodiphenylsilane is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including GC/HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for sensitive synthetic applications. Certificates of Analysis (COA) with full traceability are provided for every shipment, and we support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and reacts with strong acids/organic solvents; keep the container tightly sealed under an inert atmosphere (argon or nitrogen) for long-term storage to prevent hydrolysis. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Chloride Content	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.