Description

n-Trimethylsilyl-β-Alanine Trimethylsilyl Ester is a specialized organosilicon-protected derivative of the amino acid β-alanine. This compound is a critical reagent in advanced organic synthesis, valued for its dual silyl protection which enhances stability and reactivity under specific conditions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and fine chemical industries for the synthesis of peptides, modified amino acids, and complex bioactive molecules.

Application

• Peptide Synthesis Intermediate: Serves as a key building block for introducing β-alanine residues with protected carboxylic acid and amino functionalities, facilitating complex peptide chain assembly.
• Prodrug Development: Used in the design and synthesis of silyl-based prodrugs to improve the bioavailability and pharmacokinetic properties of active pharmaceutical ingredients (APIs).
• Chemical Derivatization Agent: Employed to temporarily protect reactive groups (amine and carboxyl) during multi-step synthetic sequences, preventing unwanted side reactions.
• Material Science Research: Acts as a precursor or modifying agent in the development of novel silicon-containing polymers and hybrid organic-inorganic materials.
• Analytical Chemistry: Utilized as a derivatization reagent in gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) for the analysis of amino acids and related compounds.

Basic Information

Product Name	n-Trimethylsilyl-β-Alanine Trimethylsilyl Ester
CAS No.	17891-86-0
Molecular Formula	C9H23NO2Si2
Molecular Weight	233.46 g/mol
Synonyms	3-[(Trimethylsilyl)amino]propanoic Acid Trimethylsilyl Ester; β-Alanine, N-(trimethylsilyl)-, Trimethylsilyl Ester; N-Trimethylsilyl-3-aminopropionic Acid Trimethylsilyl Ester; N-TMS-β-Alanine TMS Ester; 3-(Trimethylsilylamino)propionic Acid Trimethylsilyl Ester; N,O-Bis(trimethylsilyl)-β-alanine; Bis(trimethylsilyl) 3-aminopropionate
EINECS	Contact for details

Quality Control

Our n-Trimethylsilyl-β-Alanine Trimethylsilyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography (HPLC/GC) and spectroscopic methods (NMR, IR), to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed batch-specific results are provided to guarantee traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and highly volatile nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from heat and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC or HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.