Description

1-Borom-2-(Trimethylsilyl)Benzene CAS NO 17878-37-4 is a high-purity organometallic reagent featuring both a boronic ester and a trimethylsilyl protecting group on the same aromatic ring. This unique bifunctional structure makes it a versatile and valuable building block for advanced organic synthesis, particularly in cross-coupling reactions and the construction of complex molecular architectures. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key boronic ester component for constructing biaryl and heterobiaryl structures, a fundamental transformation in medicinal chemistry.
• Iterative Synthesis of Complex Molecules: The orthogonal reactivity of the boronic ester and TMS groups allows for sequential, controlled functionalization of the benzene ring.
• Protecting Group Strategy: The trimethylsilyl group can act as a temporary protecting group for the *ortho* position, which can later be deprotected and further functionalized.
• Intermediate for Liquid Crystal and OLED Materials: Used in the synthesis of advanced organic electronic materials requiring precise substitution patterns.
• Agrochemical Intermediate: Employed in the research and production of novel herbicides and fungicides with specific aromatic backbones.
• Library Synthesis for Drug Discovery: A valuable scaffold in parallel and combinatorial chemistry to generate diverse compound libraries for high-throughput screening.

Basic Information

Product Name	1-Borom-2-(Trimethylsilyl)Benzene
CAS No.	17878-37-4
Molecular Formula	C9H15BBrSi
Molecular Weight	243.02 g/mol
Synonyms	2-(Trimethylsilyl)phenylboronic acid, pinacol ester; (2-(Trimethylsilyl)phenyl)boronic acid pinacol ester; 1-Bromo-2-(trimethylsilyl)benzene; 2-Bromo-1-(trimethylsilyl)benzene; B-[2-(Trimethylsilyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-Trimethylsilylbenzeneboronic acid pinacol ester; 2-TMS-phenylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our production of 1-Borom-2-(Trimethylsilyl)Benzene adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is characterized by NMR (¹H, ¹³C, ¹¹B), GC-MS, and HPLC analysis to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) for prolonged manipulations to prevent hydrolysis of the boronic ester functionality.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.