Description

5-Carboxy-1-Pentanethiol is a bifunctional organic compound featuring both a carboxylic acid and a terminal thiol group, making it a versatile building block for chemical synthesis. This unique structure allows it to act as a linker or modifier in the creation of functionalized surfaces, polymers, and complex organic molecules. It is particularly valuable for researchers and manufacturers in the pharmaceutical, material science, and nanotechnology sectors who require precise molecular assembly and surface engineering capabilities.

Application

• Bioconjugation and Protein Modification: The thiol group can form stable bonds with gold surfaces or maleimide-activated proteins, while the carboxylic acid allows for further coupling via amide bonds, enabling the creation of complex biomolecular assemblies.
• Self-Assembled Monolayers (SAMs): Used to create functionalized surfaces on gold, silver, or other metals for applications in biosensors, corrosion inhibition, and electronic devices.
• Polymer Synthesis and Modification: Serves as a chain transfer agent (CTA) in reversible addition-fragmentation chain-transfer (RAFT) polymerization or as a monomer/cross-linker for synthesizing polymers with tailored properties.
• Nanoparticle Functionalization: Acts as a stabilizing and functionalizing ligand for quantum dots, gold nanoparticles, and other nanomaterials to impart water solubility or specific chemical reactivity.
• Peptide Synthesis: Used as a building block for introducing thiol handles into peptides, facilitating site-specific labeling or cyclization.
• Chemical Intermediate: A key precursor in the synthesis of more complex thiol-containing compounds for research and industrial applications.

Basic Information

Product Name	5-Carboxy-1-Pentanethiol
CAS No.	17689-17-7
Molecular Formula	C6H12O2S
Molecular Weight	148.22 g/mol
Synonyms	6-Mercaptohexanoic Acid; 6-Thiohexanoic Acid; 6-Sulfanylhexanoic Acid; 1-Mercapto-5-carboxypentane; 5-Carboxypentanethiol; 6-Mercaptocaproic Acid; Hexanoic acid, 6-mercapto-; NSC 3345
EINECS	241-667-8

Quality Control

Our 5-Carboxy-1-Pentanethiol is produced under stringent quality management protocols. Each batch undergoes comprehensive analytical testing to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our customers in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation of the thiol group and maintain product integrity. Keep the container in a cool, dry, and well-ventilated area, away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.