Description

(9S)-6,7,8,9-Tetrahydro-4-Methoxy-8,9-Dimethyl-1,3-Dioxolo[4,5-H]Isoquinoline is a high-purity, chiral isoquinoline derivative of significant interest in advanced organic synthesis. This compound matters as a sophisticated pharmaceutical intermediate and a versatile building block for research into bioactive molecules. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop new therapeutic agents or specialty chemicals.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of potential alkaloid-based drug candidates and central nervous system (CNS) active compounds.
• Asymmetric Synthesis Building Block: Utilized in the construction of complex natural product analogs and chiral ligands due to its defined stereochemistry at the 9-position.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Reference Standard: Used as an analytical standard in quality control laboratories for method development and impurity profiling.
• Agrochemical Research: Investigated as an intermediate for novel crop protection agents with specific biological activity.
• Academic & Institutional Research: Employed in studies focusing on organic synthesis methodologies, catalysis, and the chemistry of tetrahydroisoquinolines.

Basic Information

Product Name	(9S)-6,7,8,9-Tetrahydro-4-Methoxy-8,9-Dimethyl-1,3-Dioxolo[4,5-H]Isoquinoline
CAS No.	17627-78-0
Molecular Formula	C₁₄H₁₉NO₃
Molecular Weight	249.31 g/mol
Synonyms	(9S)-8,9-Dimethyl-4-methoxy-6,7,8,9-tetrahydro-1,3-dioxolo[4,5-h]isoquinoline; (S)-8,9-Dimethyl-4-methoxy-6,7,8,9-tetrahydro-[1,3]dioxolo[4,5-h]isoquinoline; (9S)-Tetrahydro-4-methoxy-8,9-dimethyl-1,3-dioxolo[4,5-h]isoquinoline; 1,3-Dioxolo[4,5-h]isoquinoline, 6,7,8,9-tetrahydro-4-methoxy-8,9-dimethyl-, (9S)-; (S)-(-)-8,9-Dimethyl-4-methoxy-6,7,8,9-tetrahydro-1,3-dioxolo[4,5-h]isoquinoline; NSC 339586
EINECS	Contact for details

Quality Control

Our (9S)-6,7,8,9-Tetrahydro-4-Methoxy-8,9-Dimethyl-1,3-Dioxolo[4,5-H]Isoquinoline is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.