Description

1H-Imidazole-5-Methanethiol CAS NO 17496-21-8 is a versatile sulfur-containing heterocyclic building block, valued for its unique chemical reactivity as a bifunctional ligand and precursor. This compound is critical for synthesizing complex molecules where the imidazole ring and thiol group confer specific binding or catalytic properties. It is primarily sought by researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly those targeting enzymes or receptors where the imidazole-thiol motif is pharmacologically active.
• Ligand Synthesis: Used in coordination chemistry to create chelating ligands for metal catalysts in asymmetric synthesis and polymerization processes.
• Agrochemical Research: Serves as a precursor in the development of new fungicides, herbicides, and plant growth regulators.
• Bioconjugation Chemistry: The thiol group enables selective conjugation to proteins, peptides, or other biomolecules for probe and therapeutic agent development.
• Material Science: Employed in the synthesis of functional polymers, metal-organic frameworks (MOFs), and self-assembled monolayers (SAMs).
• Chemical Biology Probes: Useful for creating activity-based probes to study enzyme function and mechanism.

Basic Information

Product Name	1H-Imidazole-5-Methanethiol
CAS No.	17496-21-8
Molecular Formula	C4H6N2S
Molecular Weight	114.17 g/mol
Synonyms	5-(Mercaptomethyl)-1H-imidazole; 1H-Imidazole-5-methanethiol; 5-Mercaptomethylimidazole; 4-Imidazolemethanethiol; Imidazole-5-ylmethanethiol; 5-(Thiomethyl)imidazole; 1H-Imidazole-4-methanethiol (tautomer); 4(5)-Mercaptomethylimidazole
EINECS	Contact for details

Quality Control

Our 1H-Imidazole-5-Methanethiol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a cool, dry, and well-ventilated place. This product is easily oxidized and moisture-sensitive; prolonged exposure to air should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.